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At certain genetic constellations there is a higher risk for arteriosclerosis and/or Alzheimer's disease (variations in E2, e.g. E4). Additional variations in the interleukin protein (IL-1A and IL-1B(+3953)) can cause higher lipid peroxidation.
Genetic variations are associated with Alzheimer's disease (also see APOE), Parkinson's disease and osteoporosis. Important for women: genetic variations are also associated with breast cancer (also see NAT2), also autoimmune disease like multiple sclerosis and rheumatoid arthritis (also see IL - 1RN).
Mutant has a higher risk of obesity (3 times more). The genetic variations of the Apolipoprotein E (ApoE) higher risk of atherosclerosis and diseases at the coronary artery. Other genetic variations in the interleukins increase the risk of a periodontitis. There will be a risk of thrombosis if the variation is in the clotting factors (Factor II, Factor V and MTHFR).